Sir Alex Ferguson's men cannot afford to commit any errors, as they welcome Swansea, in the penultimate Premier League match of the season, at Old Trafford, on Sunday.
Therefore, Manchester United need to win their final two matches and hope that Manchester City falter, if they want to lift the Premier League trophy and claim their 20th title, this term.
The red devils conceded a disastrous 1-0 defeat to Roberto Mancini’s men, on Sunday evening and are now in the second position of the stands, as the citizens have a superior goal difference of plus eight and win even sharing the same points as their neighbour rivals.
The Old Trafford outfit will welcome Swansea before travelling to Sunderland in the final game of the 2011-12 campaign, while City will lock horns with Newcastle and then host Queens Park Rangers at the Etihad Stadium.
Danny Welbeck is in doubt for the Sunday afternoon match as he was knocked by de Jong challenge in the late stages of the Manchester derby, and so Javier Hernandez is the most probable option to replace him.
As for promoted Swansea, who sit in the 12th position with 44 points, have already secured a place in the Premier League campaign, next season, after scoring a 4-4 draw to Swansea last week.
The Swans have only won one of their last seven starts, while the red devils will be determined to comeback from a 4-4 home draw against Everton. The match will kick-off on Sunday, at 16.00GMT.